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The Hypolipidemic Agent Guggulsterone Regulates the Expression of Human Bile Salt Export Pump: Dominance of Transactivation over Farsenoid X Receptor-Mediated Antagonism

Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7α-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP). The expression of CYP7A1 and BSEP is coordinately regulated by a negative feed...

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Hlavní autoři: Deng, Ruitang, Yang, Dongfang, Radke, Amy, Yang, Jian, Yan, Bingfang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114705/
https://ncbi.nlm.nih.gov/pubmed/17135343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.106.113837
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