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Structural characterization and high throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis

The human pathogen Pseudomonas aeruginosa produces a variety of virulence factors including pyoverdine, a non-ribosomally produced peptide siderophore. The maturation pathway of the pyoverdine peptide is complex and provides a unique target for inhibition. Within the pyoverdine biosynthetic cluster...

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Detalles Bibliográficos
Main Authors: Drake, Eric J., Gulick, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220798/
https://ncbi.nlm.nih.gov/pubmed/21892836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2002973
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