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The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket

In many Gram-negative pathogens, their virulent behavior is regulated by quorum sensing, in which diffusible signals such as N-acyl homoserine lactones (AHLs) act as chemical messaging compounds. Enzymatic degradation of these diffusible signals by, e.g., lactonases or amidohydrolases abolishes AHL...

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Autors principals: Bokhove, Marcel, Jimenez, Pol Nadal, Quax, Wim J., Dijkstra, Bauke W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818923/
https://ncbi.nlm.nih.gov/pubmed/20080736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911839107
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