Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc

Aqueous semi-solid polymeric gels, such as those based on hydroxyethylcellulose (HEC) and polyacrylic acid (e.g. Carbopol(®)), have a long history of use in vaginal drug delivery. However, despite their ubiquity, they often provide sub-optimal clinical performance, due to poor mucosal retention and...

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Main Authors: Forbes, Claire J., Lowry, Deborah, Geer, Leslie, Veazey, Ronald S., Shattock, Robin J., Klasse, Per Johan, Mitchnick, Mark, Goldman, Laurie, Doyle, Lara A., Muldoon, Brendan C.O., Woolfson, A. David, Moore, John P., Malcolm, R. Karl
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220778/
https://ncbi.nlm.nih.gov/pubmed/21864598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.08.006
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