Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220

OBJECTIVES: The non-nucleoside reverse transcriptase inhibitor MC1220 has potent in vitro activity against HIV type 1 (HIV-1). A liposome gel formulation of MC1220 has previously been reported to partially protect rhesus macaques against vaginal challenge with a simian HIV (SHIV). Here, we describe...

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Detalhes bibliográficos
Main Authors: Fetherston, Susan M., Geer, Leslie, Veazey, Ronald S., Goldman, Laurie, Murphy, Diarmaid J., Ketas, Thomas J., Klasse, Per Johan, Blois, Sylvain, La Colla, Paolo, Moore, John P., Malcolm, R. Karl
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543122/
https://ncbi.nlm.nih.gov/pubmed/23109186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks415
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