Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques

OBJECTIVES: To investigate the pharmacokinetics (PK) of maraviroc, a CCR5-targeted HIV-1 entry inhibitor, in rhesus macaques following vaginal administration of various maraviroc-loaded aqueous hydroxyethylcellulose (HEC) gels, and to correlate the PK data with efficacy in a single high-dose vaginal...

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Bibliographic Details
Main Authors: Malcolm, R. Karl, Forbes, Claire J., Geer, Leslie, Veazey, Ronald S., Goldman, Laurie, Johan Klasse, Per, Moore, John P.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566668/
https://ncbi.nlm.nih.gov/pubmed/23111849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks422
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