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Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques
OBJECTIVES: To investigate the pharmacokinetics (PK) of maraviroc, a CCR5-targeted HIV-1 entry inhibitor, in rhesus macaques following vaginal administration of various maraviroc-loaded aqueous hydroxyethylcellulose (HEC) gels, and to correlate the PK data with efficacy in a single high-dose vaginal...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3566668/ https://ncbi.nlm.nih.gov/pubmed/23111849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks422 |
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