Tagetitoxin Inhibits RNA Polymerase through Trapping of the Trigger Loop

Tagetitoxin (Tgt) inhibits multisubunit chloroplast, bacterial, and some eukaryotic RNA polymerases (RNAPs). A crystallographic structure of Tgt bound to bacterial RNAP apoenzyme shows that Tgt binds near the active site but does not explain why Tgt acts only at certain sites. To understand the Tgt...

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Bibliografiske detaljer
Main Authors:	Artsimovitch, Irina, Svetlov, Vladimir, Nemetski, Sondra Maureen, Epshtein, Vitaly, Cardozo, Timothy, Nudler, Evgeny
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Biochemistry and Molecular Biology 2011
Fag:	Enzymology
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3220573/ https://ncbi.nlm.nih.gov/pubmed/21976682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300889
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Tagetitoxin Inhibits RNA Polymerase through Trapping of the Trigger Loop

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