Tagetitoxin Inhibits RNA Polymerase through Trapping of the Trigger Loop

Tagetitoxin (Tgt) inhibits multisubunit chloroplast, bacterial, and some eukaryotic RNA polymerases (RNAPs). A crystallographic structure of Tgt bound to bacterial RNAP apoenzyme shows that Tgt binds near the active site but does not explain why Tgt acts only at certain sites. To understand the Tgt...

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Bibliografiska uppgifter
Huvudupphovsmän: Artsimovitch, Irina, Svetlov, Vladimir, Nemetski, Sondra Maureen, Epshtein, Vitaly, Cardozo, Timothy, Nudler, Evgeny
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Enzymology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220573/
https://ncbi.nlm.nih.gov/pubmed/21976682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300889
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