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Tagetitoxin Inhibits RNA Polymerase through Trapping of the Trigger Loop
Tagetitoxin (Tgt) inhibits multisubunit chloroplast, bacterial, and some eukaryotic RNA polymerases (RNAPs). A crystallographic structure of Tgt bound to bacterial RNAP apoenzyme shows that Tgt binds near the active site but does not explain why Tgt acts only at certain sites. To understand the Tgt...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220573/ https://ncbi.nlm.nih.gov/pubmed/21976682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300889 |
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