Tagetitoxin Inhibits RNA Polymerase through Trapping of the Trigger Loop

Tagetitoxin (Tgt) inhibits multisubunit chloroplast, bacterial, and some eukaryotic RNA polymerases (RNAPs). A crystallographic structure of Tgt bound to bacterial RNAP apoenzyme shows that Tgt binds near the active site but does not explain why Tgt acts only at certain sites. To understand the Tgt...

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Detalhes bibliográficos
Main Authors: Artsimovitch, Irina, Svetlov, Vladimir, Nemetski, Sondra Maureen, Epshtein, Vitaly, Cardozo, Timothy, Nudler, Evgeny
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220573/
https://ncbi.nlm.nih.gov/pubmed/21976682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300889
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