Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

The search for antituberculosis drugs active against persistent bacilli has led to our interest in metallodependent class II fructose-1,6-bisphosphate aldolase (FBA-tb), a key enzyme of gluconeogenesis absent from mammalian cells. Knock-out experiments at the fba-tb locus indicated that this gene is...

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Hauptverfasser: de la Paz Santangelo, Maria, Gest, Petra M., Guerin, Marcelo E., Coinçon, Mathieu, Pham, Ha, Ryan, Gavin, Puckett, Susan E., Spencer, John S., Gonzalez-Juarrero, Mercedes, Daher, Racha, Lenaerts, Anne J., Schnappinger, Dirk, Therisod, Michel, Ehrt, Sabine, Sygusch, Jurgen, Jackson, Mary
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220552/
https://ncbi.nlm.nih.gov/pubmed/21949126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.259440
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