Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

Metabolic pathways used by Mycobacterium tuberculosis (Mtb) to establish and maintain infections are important for our understanding of pathogenesis and the development of new chemotherapies. To investigate the role of fructose-1,6-bisphosphate aldolase (FBA), we engineered an Mtb strain in which FB...

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Detalhes bibliográficos
Main Authors: Puckett, Susan, Trujillo, Carolina, Eoh, Hyungjin, Marrero, Joeli, Spencer, John, Jackson, Mary, Schnappinger, Dirk, Rhee, Kyu, Ehrt, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031216/
https://ncbi.nlm.nih.gov/pubmed/24851864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004144
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