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Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

Metabolic pathways used by Mycobacterium tuberculosis (Mtb) to establish and maintain infections are important for our understanding of pathogenesis and the development of new chemotherapies. To investigate the role of fructose-1,6-bisphosphate aldolase (FBA), we engineered an Mtb strain in which FB...

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Bibliografiske detaljer
Main Authors: Puckett, Susan, Trujillo, Carolina, Eoh, Hyungjin, Marrero, Joeli, Spencer, John, Jackson, Mary, Schnappinger, Dirk, Rhee, Kyu, Ehrt, Sabine
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031216/
https://ncbi.nlm.nih.gov/pubmed/24851864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004144
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