Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

Metabolic pathways used by Mycobacterium tuberculosis (Mtb) to establish and maintain infections are important for our understanding of pathogenesis and the development of new chemotherapies. To investigate the role of fructose-1,6-bisphosphate aldolase (FBA), we engineered an Mtb strain in which FB...

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Hauptverfasser: Puckett, Susan, Trujillo, Carolina, Eoh, Hyungjin, Marrero, Joeli, Spencer, John, Jackson, Mary, Schnappinger, Dirk, Rhee, Kyu, Ehrt, Sabine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031216/
https://ncbi.nlm.nih.gov/pubmed/24851864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004144
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