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Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

Metabolic adaptation to the host niche is a defining feature of the pathogenicity of Mycobacterium tuberculosis (Mtb). In vitro, Mtb is able to grow on a variety of carbon sources, but mounting evidence has implicated fatty acids as the major source of carbon and energy for Mtb during infection. Whe...

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Bibliografiske detaljer
Main Authors: Marrero, Joeli, Rhee, Kyu Y., Schnappinger, Dirk, Pethe, Kevin, Ehrt, Sabine
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906907/
https://ncbi.nlm.nih.gov/pubmed/20439709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000715107
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