Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases

[Image: see text] Several 5-O-alkyl- and 5-C-alkyl-mannitol bis-phosphates were synthesized and comparatively assayed as inhibitors of fructose bis-phosphate aldolases (Fbas) from rabbit muscle (taken as surrogate model of the human enzyme) and from Trypanosoma brucei. A limited selectivity was foun...

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Bibliografiske detaljer
Main Authors: Mabiala-Bassiloua, Charles-Gabin, Arthus-Cartier, Guillaume, Hannaert, Véronique, Thérisod, Hélène, Sygusch, Jurgen, Thérisod, Michel
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2011
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018070/
https://ncbi.nlm.nih.gov/pubmed/24900268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200129s
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