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A Conserved Acidic Motif Is Crucial for Enzymatic Activity of Protein O-Mannosyltransferases

Protein O-mannosylation is an essential modification in fungi and mammals. It is initiated at the endoplasmic reticulum by a conserved family of dolichyl phosphate mannose-dependent protein O-mannosyltransferases (PMTs). PMTs are integral membrane proteins with two hydrophilic loops (loops 1 and 5)...

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Detalhes bibliográficos
Main Authors: Lommel, Mark, Schott, Andrea, Jank, Thomas, Hofmann, Verena, Strahl, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220539/
https://ncbi.nlm.nih.gov/pubmed/21956107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.281196
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