Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor

Metacaspases are caspase family cysteine peptidases found in plants, fungi, and protozoa but not mammals. Trypanosoma brucei is unusual in having five metacaspases (MCA1–MCA5), of which MCA1 and MCA4 have active site substitutions, making them possible non-enzymatic homologues. Here we demonstrate t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Proto, William R., Castanys-Munoz, Esther, Black, Alana, Tetley, Laurence, Moss, Catherine X., Juliano, Luiz, Coombs, Graham H., Mottram, Jeremy C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Microbiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220528/
https://ncbi.nlm.nih.gov/pubmed/21949125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292334
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