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Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor
Metacaspases are caspase family cysteine peptidases found in plants, fungi, and protozoa but not mammals. Trypanosoma brucei is unusual in having five metacaspases (MCA1–MCA5), of which MCA1 and MCA4 have active site substitutions, making them possible non-enzymatic homologues. Here we demonstrate t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220528/ https://ncbi.nlm.nih.gov/pubmed/21949125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292334 |
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