Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor

Metacaspases are caspase family cysteine peptidases found in plants, fungi, and protozoa but not mammals. Trypanosoma brucei is unusual in having five metacaspases (MCA1–MCA5), of which MCA1 and MCA4 have active site substitutions, making them possible non-enzymatic homologues. Here we demonstrate t...

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書誌詳細
主要な著者: Proto, William R., Castanys-Munoz, Esther, Black, Alana, Tetley, Laurence, Moss, Catherine X., Juliano, Luiz, Coombs, Graham H., Mottram, Jeremy C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
Microbiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220528/
https://ncbi.nlm.nih.gov/pubmed/21949125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292334
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