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Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence

ICP is a chagasin-family natural tight binding inhibitor of Clan CA, family C1 cysteine peptidases (CPs). We investigated the role of ICP in Trypanosoma brucei by generating bloodstream form ICP-deficient mutants (Δicp). A threefold increase in CP activity was detected in lysates of Δicp, which was...

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Détails bibliographiques
Auteurs principaux: Santos, Camila C, Coombs, Graham H, Lima, Ana Paula C A, Mottram, Jeremy C
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680270/
https://ncbi.nlm.nih.gov/pubmed/17944830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2007.05970.x
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