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Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence
ICP is a chagasin-family natural tight binding inhibitor of Clan CA, family C1 cysteine peptidases (CPs). We investigated the role of ICP in Trypanosoma brucei by generating bloodstream form ICP-deficient mutants (Δicp). A threefold increase in CP activity was detected in lysates of Δicp, which was...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680270/ https://ncbi.nlm.nih.gov/pubmed/17944830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2007.05970.x |
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