Design and evaluation of Trypanosoma brucei metacaspase inhibitors

Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which needs further characterization to support the discover...

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Библиографические подробности
Главные авторы: Berg, Maya, Van der Veken, Pieter, Joossens, Jurgen, Muthusamy, Venkatraj, Breugelmans, Matthias, Moss, Catherine X., Rudolf, Jana, Cos, Paul, Coombs, Graham H., Maes, Louis, Haemers, Achiel, Mottram, Jeremy C., Augustyns, Koen
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845880/
https://ncbi.nlm.nih.gov/pubmed/20167486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.099
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