α-Ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB

Cysteine proteases of the papain superfamily are present in nearly all eukaryotes and also play pivotal roles in the biology of parasites. Inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping sickness, Chagas’ disease and leishmaniasis....

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Bibliographische Detailangaben
Hauptverfasser: Steert, Koen, Berg, Maya, Mottram, Jeremy C., Westrop, Gareth D., Coombs, Graham H., Cos, Paul, Maes, Louis, Joossens, Jurgen, Van der Veken, Pieter, Haemers, Achiel, Augustyns, Koen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245848/
https://ncbi.nlm.nih.gov/pubmed/20799311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000265
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