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Identification of Semicarbazones, Thiosemicarbazones and Triazine Nitriles as Inhibitors of Leishmania mexicana Cysteine Protease CPB

Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping sickness, Chagas’ disease and leishmaniasis....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schröder, Jörg, Noack, Sandra, Marhöfer, Richard J., Mottram, Jeremy C., Coombs, Graham H., Selzer, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797739/
https://ncbi.nlm.nih.gov/pubmed/24146999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077460
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