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Design and evaluation of Trypanosoma brucei metacaspase inhibitors
Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which needs further characterization to support the discover...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2845880/ https://ncbi.nlm.nih.gov/pubmed/20167486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.099 |
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