Design and evaluation of Trypanosoma brucei metacaspase inhibitors

Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which needs further characterization to support the discover...

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Main Authors: Berg, Maya, Van der Veken, Pieter, Joossens, Jurgen, Muthusamy, Venkatraj, Breugelmans, Matthias, Moss, Catherine X., Rudolf, Jana, Cos, Paul, Coombs, Graham H., Maes, Louis, Haemers, Achiel, Mottram, Jeremy C., Augustyns, Koen
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845880/
https://ncbi.nlm.nih.gov/pubmed/20167486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.099
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