p21-activated Kinase 3 (PAK3) Protein Regulates Synaptic Transmission through Its Interaction with the Nck2/Grb4 Protein Adaptor

Mutations in the p21-activated kinase 3 gene (pak3) are responsible for nonsyndromic forms of mental retardation. Expression of mutated PAK3 proteins in hippocampal neurons induces abnormal dendritic spine morphology and long term potentiation anomalies, whereas pak3 gene invalidation leads to cogni...

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Detalhes bibliográficos
Main Authors: Thévenot, Emmanuel, Moreau, Alexandre William, Rousseau, Véronique, Combeau, Gaëlle, Domenichini, Florence, Jacquet, Claire, Goupille, Olivier, Amar, Muriel, Kreis, Patricia, Fossier, Philippe, Barnier, Jean-Vianney
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220523/
https://ncbi.nlm.nih.gov/pubmed/21949127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262246
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