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Mechanism of HIV Reverse Transcriptase Inhibition by Zinc: FORMATION OF A HIGHLY STABLE ENZYME-(PRIMER-TEMPLATE) COMPLEX WITH PROFOUNDLY DIMINISHED CATALYTIC ACTIVITY
Several physiologically relevant cations including Ca(2+), Mn(2+), and Zn(2+) have been shown to inhibit HIV reverse transcriptase (RT), presumably by competitively displacing one or more Mg(2+) ions bound to RT. We analyzed the effects of Zn(2+) on reverse transcription and compared them to Ca(2+)...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220506/ https://ncbi.nlm.nih.gov/pubmed/21953456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.289850 |
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