Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca(2+) channel complex

Chronic pain hypersensitivity depends on N-type voltage-gated calcium channels (CaV2.2). However, the use of CaV2.2 blockers in pain therapeutics is limited by side effects that result from inhibited physiological functions of these channels. Here we report suppression of both inflammatory and neuro...

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Main Authors: Brittain, Joel M., Duarte, Djane B., Wilson, Sarah M., Zhu, Weiguo, Ballard, Carrie, Johnson, Phillip L., Liu, Naikui, Xiong, Wenhui, Ripsch, Matthew S., Wang, Yuying, Fehrenbacher, Jill C., Fitz, Stephanie D., Khanna, May, Park, Chul-Kyu, Schmutzler, Brian S., Cheon, Bo Myung, Due, Michael R., Brustovetsky, Tatiana, Ashpole, Nicole M., Hudmon, Andy, Meroueh, Samy O., Hingtgen, Cynthia M., Brustovetsky, Nikolay, Ji, Ru-Rong, Hurley, Joyce H., Jin, Xiaoming, Shekhar, Anantha, Xu, Xiao-Ming, Oxford, Gerry S., Vasko, Michael R., White, Fletcher A., Khanna, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219927/
https://ncbi.nlm.nih.gov/pubmed/21642979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2345
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