CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy

BACKGROUND: The ubiquity of protein-protein interactions in biological signaling offers ample opportunities for therapeutic intervention. We previously identified a peptide, designated CBD3, that suppressed inflammatory and neuropathic behavioral hypersensitivity in rodents by inhibiting the ability...

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Detalhes bibliográficos
Main Authors: Piekarz, Andrew D, Due, Michael R, Khanna, May, Wang, Bo, Ripsch, Matthew S, Wang, Ruizhong, Meroueh, Samy O, Vasko, Michael R, White, Fletcher A, Khanna, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502107/
https://ncbi.nlm.nih.gov/pubmed/22828369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-54
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