A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca(2+) CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY

Biological, genetic, and clinical data provide compelling proof for N-type voltage-gated calcium channels (CaV2.2) as therapeutic targets for chronic pain. While decreasing channel function is ultimately anti-nociceptive, directly targeting the channel can lead to multiple adverse effects. Targeting...

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Autori principali: Ripsch, Matthew S., Ballard, Carrie J., Khanna, May, Hurley, Joyce H., White, Fletcher A., Khanna, Rajesh
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365854/
https://ncbi.nlm.nih.gov/pubmed/22662308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s13380-012-0002-4
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