Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases

BACKGROUND: Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Si...

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Bibliografiske detaljer
Main Authors: Zhang, Xiaotun, Morrissey, Colm, Sun, Shihua, Ketchandji, Melanie, Nelson, Peter S., True, Lawrence D., Vakar-Lopez, Funda, Vessella, Robert L., Plymate, Stephen R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219707/
https://ncbi.nlm.nih.gov/pubmed/22114732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027970
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