Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling despite AR blockade. Recent studies suggest that these activities are due to the generation of constitutively active AR splice variants, but the mechanisms by which these...

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Autors principals: Sun, Shihua, Sprenger, Cynthia C.T., Vessella, Robert L., Haugk, Kathleen, Soriano, Kathryn, Mostaghel, Elahe A., Page, Stephanie T., Coleman, Ilsa M., Nguyen, Holly M., Sun, Huiying, Nelson, Peter S., Plymate, Stephen R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912187/
https://ncbi.nlm.nih.gov/pubmed/20644256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41824
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