Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling despite AR blockade. Recent studies suggest that these activities are due to the generation of constitutively active AR splice variants, but the mechanisms by which these...

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Détails bibliographiques
Auteurs principaux: Sun, Shihua, Sprenger, Cynthia C.T., Vessella, Robert L., Haugk, Kathleen, Soriano, Kathryn, Mostaghel, Elahe A., Page, Stephanie T., Coleman, Ilsa M., Nguyen, Holly M., Sun, Huiying, Nelson, Peter S., Plymate, Stephen R.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912187/
https://ncbi.nlm.nih.gov/pubmed/20644256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41824
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