Molecular Pathogenesis of Secondary Acute Promyelocytic Leukemia

Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise to acute promyelocytic leukemia (APL). An increas...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Joannides, M., Mays, A. N., Mistry, A. R., Hasan, S. K., Reiter, A., Wiemels, J. L., Felix, C. A., Coco, F. Lo, Osheroff, N., Solomon, E., Grimwade, D.
Format: Artigo
Langue:Inglês
Publié: Università Cattolica del Sacro Cuore 2011
Sujets:
Review Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219647/
https://ncbi.nlm.nih.gov/pubmed/22110895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4084/MJHID.2011.045
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