Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17) translocation is a well-recognized complication of cancer treatment with agents targeting topoisomerase II. However, cases are emerging after mitoxantrone therapy for multiple sclerosis (MS). Analysis of 12 cases of mitoxantrone-rela...

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Detalhes bibliográficos
Main Authors: Hasan, Syed Khizer, Mays, Ashley N., Ottone, Tiziana, Ledda, Antonio, La Nasa, Giorgio, Cattaneo, Chiara, Borlenghi, Erika, Melillo, Lorella, Montefusco, Enrico, Cervera, José, Stephen, Christopher, Satchi, Gnanam, Lennard, Anne, Libura, Marta, Byl, Jo Ann W., Osheroff, Neil, Amadori, Sergio, Felix, Carolyn A., Voso, Maria Teresa, Sperr, Wolfgang R., Esteve, Jordi, Sanz, Miguel A., Grimwade, David, Lo-Coco, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954750/
https://ncbi.nlm.nih.gov/pubmed/18650449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-115600
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