Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17)(q22;q21) involving the PML and RARA genes is associated with exposure to agents targeting topoisomerase II (topoII), particularly mitoxantrone and epirubicin. We previously have shown that mitoxantrone preferentially induces topoII-m...

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Autori principali: Mays, Ashley N., Osheroff, Neil, Xiao, Yuanyuan, Wiemels, Joseph L., Felix, Carolyn A., Byl, Jo Ann W., Saravanamuttu, Kandeepan, Peniket, Andrew, Corser, Robert, Chang, Cherry, Hoyle, Christine, Parker, Anne N., Hasan, Syed K., Lo-Coco, Francesco, Solomon, Ellen, Grimwade, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808156/
https://ncbi.nlm.nih.gov/pubmed/19884644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-235051
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