Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17)(q22;q21) involving the PML and RARA genes is associated with exposure to agents targeting topoisomerase II (topoII), particularly mitoxantrone and epirubicin. We previously have shown that mitoxantrone preferentially induces topoII-m...

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Detalhes bibliográficos
Main Authors: Mays, Ashley N., Osheroff, Neil, Xiao, Yuanyuan, Wiemels, Joseph L., Felix, Carolyn A., Byl, Jo Ann W., Saravanamuttu, Kandeepan, Peniket, Andrew, Corser, Robert, Chang, Cherry, Hoyle, Christine, Parker, Anne N., Hasan, Syed K., Lo-Coco, Francesco, Solomon, Ellen, Grimwade, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808156/
https://ncbi.nlm.nih.gov/pubmed/19884644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-235051
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