Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17)(q22;q21) involving the PML and RARA genes is associated with exposure to agents targeting topoisomerase II (topoII), particularly mitoxantrone and epirubicin. We previously have shown that mitoxantrone preferentially induces topoII-m...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Mays, Ashley N., Osheroff, Neil, Xiao, Yuanyuan, Wiemels, Joseph L., Felix, Carolyn A., Byl, Jo Ann W., Saravanamuttu, Kandeepan, Peniket, Andrew, Corser, Robert, Chang, Cherry, Hoyle, Christine, Parker, Anne N., Hasan, Syed K., Lo-Coco, Francesco, Solomon, Ellen, Grimwade, David
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808156/
https://ncbi.nlm.nih.gov/pubmed/19884644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-235051
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires