Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17)(q22;q21) involving the PML and RARA genes is associated with exposure to agents targeting topoisomerase II (topoII), particularly mitoxantrone and epirubicin. We previously have shown that mitoxantrone preferentially induces topoII-m...

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Main Authors: Mays, Ashley N., Osheroff, Neil, Xiao, Yuanyuan, Wiemels, Joseph L., Felix, Carolyn A., Byl, Jo Ann W., Saravanamuttu, Kandeepan, Peniket, Andrew, Corser, Robert, Chang, Cherry, Hoyle, Christine, Parker, Anne N., Hasan, Syed K., Lo-Coco, Francesco, Solomon, Ellen, Grimwade, David
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808156/
https://ncbi.nlm.nih.gov/pubmed/19884644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-235051
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