Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers

INTRODUCTION: Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg. METHODS: Immunop...

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Detalhes bibliográficos
Main Authors: Yan, Max, Jene, Nicholas, Byrne, David, Millar, Ewan KA, O'Toole, Sandra A, McNeil, Catriona M, Bates, Gaynor J, Harris, Adrian L, Banham, Alison H, Sutherland, Robert L, Fox, Stephen B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219210/
https://ncbi.nlm.nih.gov/pubmed/21521526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2869
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