Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers

INTRODUCTION: RAD21 is a component of the cohesin complex, which is essential for chromosome segregation and error-free DNA repair. We assessed its prognostic and predictive power in a cohort of in situ and invasive breast cancers, and its effect on chemosensitivity in vitro. METHODS: RAD21 immunohi...

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Autores principales: Xu, Huiling, Yan, Max, Patra, Jennifer, Natrajan, Rachael, Yan, Yuqian, Swagemakers, Sigrid, Tomaszewski, Jonathan M, Verschoor, Sandra, Millar, Ewan KA, van der Spek, Peter, Reis-Filho, Jorge S, Ramsay, Robert G, O'Toole, Sandra A, McNeil, Catriona M, Sutherland, Robert L, McKay, Michael J, Fox, Stephen B
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109576/
https://ncbi.nlm.nih.gov/pubmed/21255398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2814
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