Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Summary: Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intestinal adenomagenesis. Haploinsufficiency of the cohesin Rad21 influences multiple initiating events in colorectal cancer (CRC). We identify Rad21 as a gatekeeper o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C. Eder, Robyn L. Ward, Nicholas J. Hawkins, Richard W. Tothill, Long Chen, Neil J. Mortensen, Stephen B. Fox, Michael J. McKay, Robert G. Ramsay
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014-12-01
coleção:Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124714009280
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados