The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

INTRODUCTION: The seven in absentia homolog 2 (SIAH2) protein plays a significant role in the hypoxic response by regulating the abundance of hypoxia-inducible factor-α; however, its role in breast carcinoma is unclear. We investigated the frequency and expression pattern of SIAH2 in two independent...

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Detalhes bibliográficos
Main Authors: Chan, Peter, Möller, Andreas, Liu, Mira CP, Sceneay, Jaclyn E, Wong, Christina SF, Waddell, Nic, Huang, Katie T, Dobrovic, Alexander, Millar, Ewan KA, O'Toole, Sandra A, McNeil, Catriona M, Sutherland, Robert L, Bowtell, David D, Fox, Stephen B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109588/
https://ncbi.nlm.nih.gov/pubmed/21306611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2828
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