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Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase

The cellular response to an inflammatory stressor requires a proinflammatory cellular activation followed by a controlled resolution of the response to restore homeostasis. We hypothesized that biliverdin reductase (BVR) by binding biliverdin (BV) quells the cellular response to endotoxin-induced in...

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Autors principals: Wegiel, Barbara, Gallo, David, Csizmadia, Eva, Roger, Thierry, Kaczmarek, Elzbieta, Harris, Clair, Zuckerbraun, Brian S., Otterbein, Leo E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219137/
https://ncbi.nlm.nih.gov/pubmed/22042868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108571108
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