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Gating charge interactions with the S1 segment during activation of a Na(+) channel voltage sensor

Voltage-gated Na(+) channels initiate action potentials during electrical signaling in excitable cells. Opening and closing of the pore of voltage-gated ion channels are mechanically linked to voltage-driven outward movement of the positively charged S4 transmembrane segment in their voltage sensors...

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Autors principals: DeCaen, Paul G., Yarov-Yarovoy, Vladimir, Scheuer, Todd, Catterall, William A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219111/
https://ncbi.nlm.nih.gov/pubmed/22042870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116449108
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