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Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation

The S4 transmembrane segments of voltage-gated ion channels move outward on depolarization, initiating a conformational change that opens the pore, but the mechanism of S4 movement is unresolved. One structural model predicts sequential formation of ion pairs between the S4 gating charges and negati...

詳細記述

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書誌詳細
主要な著者: DeCaen, Paul G., Yarov-Yarovoy, Vladimir, Zhao, Yong, Scheuer, Todd, Catterall, William A.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567506/
https://ncbi.nlm.nih.gov/pubmed/18809926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806486105
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