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Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation
The S4 transmembrane segments of voltage-gated ion channels move outward on depolarization, initiating a conformational change that opens the pore, but the mechanism of S4 movement is unresolved. One structural model predicts sequential formation of ion pairs between the S4 gating charges and negati...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567506/ https://ncbi.nlm.nih.gov/pubmed/18809926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806486105 |
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