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Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation

The S4 transmembrane segments of voltage-gated ion channels move outward on depolarization, initiating a conformational change that opens the pore, but the mechanism of S4 movement is unresolved. One structural model predicts sequential formation of ion pairs between the S4 gating charges and negati...

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Détails bibliographiques
Auteurs principaux: DeCaen, Paul G., Yarov-Yarovoy, Vladimir, Zhao, Yong, Scheuer, Todd, Catterall, William A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567506/
https://ncbi.nlm.nih.gov/pubmed/18809926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806486105
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