Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3

INTRODUCTION: Metastasis is a common event and the main cause of death in cancer patients. Lymphangiogenesis refers to the formation of new lymphatic vessels and is thought to be involved in the development of metastasis. Sunitinib is a multi-kinase inhibitor that blocks receptor tyrosine kinase act...

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Detalhes bibliográficos
Main Authors: Kodera, Yasuo, Katanasaka, Yasufumi, Kitamura, Yuka, Tsuda, Hitoshi, Nishio, Kazuto, Tamura, Tomohide, Koizumi, Fumiaki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218955/
https://ncbi.nlm.nih.gov/pubmed/21693010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2903
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