Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma

BACKGROUND: Expression of the constitutively activated mutant EGFR variant III (EGFRvIII), the most common mutation in glioblastoma multiforme (GBMs), has been clinically correlated with tumor proliferation, invasion, and angiogenesis. In this study, we examined the role of EGFRvIII on the tumor mic...

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Detalhes bibliográficos
Main Authors: Katanasaka, Yasufumi, Kodera, Yasuo, Kitamura, Yuka, Morimoto, Tatsuya, Tamura, Tomohide, Koizumi, Fumiaki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641008/
https://ncbi.nlm.nih.gov/pubmed/23617883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-31
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