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MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity
The tumor suppressor p53 is extensively regulated by post-translational modification, including modification by the small ubiquitin-related modifier SUMO. We show here that MDM2, previously shown to promote ubiquitin, Nedd8 and SUMO-1 modification of p53, can also enhance conjugation of endogenous S...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3218624/ https://ncbi.nlm.nih.gov/pubmed/21900752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.18.17436 |
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