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SUMO-1 modification activates the transcriptional response of p53.
The p53 tumour suppressor protein is regulated by ubiquitin-mediated proteasomal degradation. In normal cells p53 is constitutively ubiquitylated by the Mdm2 ubiquitin ligase. When the p53 response is activated by stress signals p53 levels rise due to inhibition of this degradative pathway. Here we...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171708/ https://ncbi.nlm.nih.gov/pubmed/10562557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6455 |
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