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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.
The growth-suppressive properties of p53 are controlled by posttranslational modifications and by regulation of its turnover rate. Here we show that p53 can be modified in vitro and in vivo by conjugation to the small ubiquitin-like protein SUMO-1. A lysine residue at amino acid position 386 of p53...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171709/ https://ncbi.nlm.nih.gov/pubmed/10562558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6462 |
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