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SUMO-specific protease 2 in Mdm2-mediated regulation of p53
Genetic analysis in mice has revealed a key genetic pathway, SUMO-specific protease 2 (SENP2)-Mdm2-p53, essential for trophoblast development. Targeted disruption of SENP2 impairs the G–S transition required for mitotic and endoreduplication cell cycles during the expansion of trophoblast stem cells...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081924/ https://ncbi.nlm.nih.gov/pubmed/21183956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.168 |
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