Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive lung cancer subtype in need of better therapies. Histone deacetylase inhibitors (HDIs) promote increased lysine acetylation in nucleosomal histones and are thought to relax chromatin, thereby allowing increased access of transcription factors and DNA da...

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Bibliographische Detailangaben
Hauptverfasser: Luchenko, Victoria L, Salcido, Crystal D, Zhang, Yongwei, Agama, Keli, Komlodi-Pasztor, Edina, Murphy, Robert F, Giaccone, Giuseppe, Pommier, Yves, Bates, Susan E, Varticovski, Lyuba
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
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Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218622/
https://ncbi.nlm.nih.gov/pubmed/21900747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.18.17190
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