Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive lung cancer subtype in need of better therapies. Histone deacetylase inhibitors (HDIs) promote increased lysine acetylation in nucleosomal histones and are thought to relax chromatin, thereby allowing increased access of transcription factors and DNA da...

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Detalhes bibliográficos
Main Authors: Luchenko, Victoria L, Salcido, Crystal D, Zhang, Yongwei, Agama, Keli, Komlodi-Pasztor, Edina, Murphy, Robert F, Giaccone, Giuseppe, Pommier, Yves, Bates, Susan E, Varticovski, Lyuba
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218622/
https://ncbi.nlm.nih.gov/pubmed/21900747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.18.17190
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