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Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. Using molecular, cellular and biochemical approaches, we demonstrate that...

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Bibliografiske detaljer
Main Authors: Chen, Aishe, Dong, Lixue, Leffler, Nancy R., Asch, Adam S., Witte, Owen N., Yang, Li V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217975/
https://ncbi.nlm.nih.gov/pubmed/22110680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027586
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