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Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood perfusion. However, the molecular mechanisms by which cells sense and respond t...

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Main Authors: Dong, Lixue, Li, Zhigang, Leffler, Nancy R., Asch, Adam S., Chi, Jen-Tsan, Yang, Li V.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628782/
https://ncbi.nlm.nih.gov/pubmed/23613998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061991
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