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Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood perfusion. However, the molecular mechanisms by which cells sense and respond t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dong, Lixue, Li, Zhigang, Leffler, Nancy R., Asch, Adam S., Chi, Jen-Tsan, Yang, Li V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628782/
https://ncbi.nlm.nih.gov/pubmed/23613998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061991
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