Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner

The microenvironment of the lung in asthma is acidic, yet the effect of acidity on inflammatory cells has not been well established. We now demonstrate that acidity inhibits eosinophil apoptosis and increases cellular viability in a dose-dependent manner between pH 7.5 and 6.0. Notably, acidity indu...

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Detalhes bibliográficos
Main Authors: Kottyan, Leah C., Collier, Ann R., Cao, Khanh H., Niese, Kathryn A., Hedgebeth, Megan, Radu, Caius G., Witte, Owen N., Khurana Hershey, Gurjit K., Rothenberg, Marc E., Zimmermann, Nives
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756132/
https://ncbi.nlm.nih.gov/pubmed/19641187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-220681
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