An intact PDZ motif is essential for correct P2Y(12) purinoceptor traffic in human platelets

The platelet P2Y(12) purinoceptor (P2Y(12)R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y(12)R function is compromised after dele...

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Bibliografiska uppgifter
Huvudupphovsmän: Nisar, Shaista, Daly, Martina E., Federici, Augusto B., Artoni, Andrea, Mumford, Andrew D., Watson, Stephen P., Mundell, Stuart J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2011
Ämnen:
Platelets and Thrombopoiesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217363/
https://ncbi.nlm.nih.gov/pubmed/21937696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-336826
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